Investigator's information
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| IDENTIFICATION AND CONTACT INFORMATION |
| Last name: | MacVicar |
First name: | Brian A |
| Address: | Department of Psychiatry
Brain Research Centre
University of British Columbia
2211 Wesbrook Mall
Vancouver (British Columbia)
V6T 2B5 |
Fax: | (604) 822-7299 |
| BC academic affiliation: | University of British Columbia |
| Department: | Brain Res Ctr/ Dept Psychiatry |
| E-mail address: |
bmacvicar@brain.ubc.ca |
BC research location(s): |
Vancouver Hospital & Health Sciences Centre (UBC Hospital)
University of British Columbia - Vancouver Campus |
| Web Page: |
http://www.macvicarlab.ca
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MSFHR Research Unit(s): |
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| Status: | Researcher |
| Last update: |
31/08/2010
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| TRAINING AND CREDENTIALS |
| Diploma / Credentials |
Specialty |
Year |
Institution |
| Postdoctorate |
Neurophysiology |
1983 |
New York University |
| Postdoctorate |
Neuroscience |
1981 |
Michigan State University |
| Doctorate (PhD) |
Neurophysiology |
1980 |
University of Toronto |
| Master's |
Neurophysiology |
1978 |
University of Toronto |
| Bachelor's, Honours |
Zoology |
1976 |
University of Toronto |
| Last update: |
25/10/2006
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| AREAS OF EXPERTISE |
| Area of research: |
Health sciences |
| Disciplines trained in: |
Neurosciences |
| Research disciplines: |
Neurosciences |
| Research topics: |
Neuronal and Synaptic Activity (Neurosciences, Mental Health and Addiction)
Central Nervous System Organic Diseases (Neurosciences, Mental Health and Addiction)
Cerebrovascular Accident (Neurosciences, Mental Health and Addiction)
Migraine (Neurosciences, Mental Health and Addiction) |
| Fields of application: |
Biomedical Aspects of Human Health
Pathogenesis and Treatment of Diseases |
| Last update: |
31/08/2010
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| TECHNOLOGICAL APPLICATIONS |
| Technological applications: |
Research equipment |
| Last update: |
31/08/2010
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| RESEARCH ACTIVITIES - Description used by investigators to specify their area of expertise. |
| Key words: |
Voltage Clamping, Synaptic physiology, Neurophysiology, Astrocytes, Two-photon laser scanning, Intracellular Ca imaging, Brain slices, seizure discharges, Cell culture, Epilepsy |
| Research interests: |
1)examining the roles for astrocytes in the regulation of cerebral blood flow and synaptic transmission; 2) generation of seizure like plateau potentials by GPCR upregulation of R-type calcium currents and insertion of TRPC channels; 3) signal transduction mechanisms underlying presynaptic inhibition; 4) contribution of novel cation channels activated by ischemia to excitotoxicity. |
| Last update: |
31/08/2010
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| RECENT AND REPRESENTATIVE PUBLICATIONS |
| Authors |
| Title (article or book chapter) |
| Year |
Volume |
Number |
Pages |
Journal or book |
Editors |
City and publishing house |
| Gordon G R J , Iremonger K J , Kantevari S, Ellis-Davies G C R, MacVicar B A, Bains J S |
| "Astrocyte mediated distributed plasticity at hypothalamic glutamate synapses" |
| 2009 |
64 |
3 |
pp. 391-403 |
Neuron |
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| Thompson R J, Jackson M F, Olah M, Rungta R, Hines D J, Beazely M A, MacDonald J A, MacVicar B A |
| "Activation of pannexin-1 hemmichannels augments aberrant bursting in the hippocampus" |
| 2008 |
322 |
5907 |
pp. 1555-1559 |
Science |
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| Gordon G R J, Choi H B, Rungta R, Ellis-Davies G C R, MacVicar B A |
| "Brain metabolism dictates the polarity of astrocytes control over arterioles" |
| 2008 |
456 |
7223 |
pp. 745-749 |
Nature |
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| Last update: |
31/08/2010
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| LANGUAGE COMPETENCIES |
| Understand: |
English |
| Read: |
English, French |
| Write: |
English |
| Speak: |
English |
| Last update: |
31/08/2010
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